The flights will operate between May and September with seats now on sale from £39.99 one-way including taxes and charges.
Mike Rutter, of Flybe said: "We are pleased to announce these three new routes to France from Southampton that complement our 10 existing routes for those travelling to and from regional France.
"They will further position Southampton as the most convenient gateway into the South of England from France and also serve to underpin inbound tourism that is so key to local economies especially in these hard-pressed times."
Details of the three new Flybe summer 2011 routes from Southampton as follows:
Operates twice weekly Monday and Friday from May 27 to September 10, 2011.
Depart Southampton 1045, arrive Beziers 1340
Depart Beziers 1420, arrive Southampton 1505
Operates Monday, Thursday and Saturday from May 21 to September 10, 2011
Monday and Thursday flights
Depart Southampton 1050, arrive Clermont-Ferrand 1325
Depart Clermont-Ferrand 1350, arrive Southampton 1425
Depart Southampton 1140, arrive Clermont-Ferrand 1415
Depart Clermont-Ferrand 1440, arrive Southampton 1515
Operates twice weekly Wednesday and Sunday from May 25 to September 10, 2011.
Depart Southampton 1045, arrive Pau 1340
Depart Pau 1410, arrive Southampton 1505
Depart Southampton 1405, arrive Pau 1700
Depart Pau 1730, arrive Southampton 1825
These new routes come soon after a code-sharing agreement was signed between Flybe and Air France, opening up new links between the UK and France for passengers of each airline.